Wiese, who was not even on the bench for the first Test, comes straight into the starting lineup in place of Kwagga Smith, who drops to the bench. It is just the second Test appearance for 25-year-old Wiese, who came off the bench to face Georgia last month.
The other two changes come at prop. Steven Kitshoff comes in for Ox Nche, who is injured, and wins his 50th cap. Frans Malherbe comes in on the tighthead for Trevor Nyakane.
Nyakane and Saracens’ Vincent Koch take a place on a 6-2 bench. Both men prefer to scrum on the tighthead, but coach Jacques Nienaber is confident that either – but especially Nyakane – can play on the loosehead.
Marco van Staden comes onto the bench for Elton Jantjes to readjust the balance to six forwards and two backs.
“This is a massive game for us; it is do or die in order to stay in the race to win the series and we selected a team that offers continuity in selection, but also that we thought would be the best suited to achieve the objectives we have set for this match,” said Nienaber.
“We have had an extra week on the training field after a few disruptive weeks in the build-up to the opening Test, so we are confident that the players in the squad will be able to deliver on the physicality and grit that will be required in this match.
“We disappointed ourselves last week, and we all know how important it is to bounce back with a strong performance and show our fighting spirit and pride as a team and nation.
“For most players the Castle Lager Lions Series is a once in a lifetime opportunity, and we desperately want to win the series, so we will fight as hard as we can on the field to win this week so that we can achieve that goal.”